|
Symbol Name ID |
Myd88
myeloid differentiation primary response gene 88 MGI:108005 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Monoclonal immunoglobulin M proteinemia |
Polyclonal elevation of IgM |
Epistaxis |
Gingival bleeding |
Gastrointestinal hemorrhage |
Retinal hemorrhage |
Purpura |
Normocytic anemia |
Impaired lymphocyte transformation with phytohemagglutinin |
Abnormality of neutrophils |
Leukemia |
Hypercoagulability |
Lymphoma |
Elevated erythrocyte sedimentation rate |
Splenomegaly |
| Disease(s) Associated with MYD88 | |||||||||||||||
| lymphoplasmacytic lymphoma |
| Mouse Phenotypes | hematopoietic system phenotype |
abnormal dendritic cell differentiation |
decreased B cell proliferation |
increased B cell proliferation |
enlarged spleen |
abnormal somatic hypermutation frequency |
abnormal T-helper 1 cell differentiation |
decreased mean corpuscular volume |
decreased neutrophil cell number |
increased dendritic cell number |
increased germinal center B cell number |
increased plasma cell number |
decreased effector memory CD4-positive, alpha-beta T cell number |
decreased macrophage cell number |
decreased monocyte cell number |
decreased leukocyte cell number |
abnormal splenic cell ratio |
abnormal neutrophil physiology |
increased IgA level |
increased IgE level |
decreased IgG1 level |
increased IgG1 level |
decreased IgG2b level |
decreased IgG2c level |
decreased IgG3 level |
decreased IgG level |
increased IgM level |
abnormal NK cell physiology |
abnormal T cell physiology |
abnormal CD4-positive, alpha-beta T cell physiology |
abnormal T-helper 1 physiology |
abnormal T-helper 17 cell physiology |
abnormal NK T cell physiology |
abnormal memory T cell physiology |
abnormal macrophage physiology |
abnormal microglial cell physiology |
|
| Availability | Mouse Genotype | ||||||||||||||||||||||||||||||||||||
| Myd88lkd/Myd88lkd | |||||||||||||||||||||||||||||||||||||
| Myd88poc/Myd88poc | |||||||||||||||||||||||||||||||||||||
| Myd88tm1.1Defr/Myd88tm1.1Defr | |||||||||||||||||||||||||||||||||||||
| Myd88tm1a(EUCOMM)Wtsi/Myd88tm1a(EUCOMM)Wtsi | |||||||||||||||||||||||||||||||||||||
| Myd88tm1Aki/Myd88tm1Aki | * | ||||||||||||||||||||||||||||||||||||
| Myd88tm1Hlz/Myd88tm1Hlz | |||||||||||||||||||||||||||||||||||||
| Cd19tm1(cre)Cgn/Cd19+ Myd88em1.1Rsky/Myd88em1.1Rsky (conditional) |
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| Myd88tm1.1Medz/Myd88tm1.1Medz Tg(Cd4-cre)1Cwi/0 (conditional) |
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| Myd88tm1Defr/Myd88tm1Defr Tg(Itgax-cre)1-1Reiz/0 (conditional) |
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| Myd88tm1Defr/Myd88tm1Defr Commd10Tg(Vav1-icre)A2Kio/Commd10+ (conditional) |
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| Cd19tm1(cre)Cgn/Cd19+ Myd88em1.1Rsky/Myd88+ (conditional) |
* | ||||||||||||||||||||||||||||||||||||
| Cd19tm1(cre/ERT2)Rsky/Cd19+ Myd88em1.1Rsky/Myd88+ (conditional) |
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| Ighg1tm1(cre)Cgn/Ighg1+ Myd88em1.1Rsky/Myd88+ (conditional) |
* | ||||||||||||||||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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